Clareity

Fruitful discussions and sharing ideas at Clare College, Cambridge

Clareity Symposium 2015 Programme

Programme

10.50 – Registration opens, Gillespie Centre

11.10 – Welcome by the Clareity President, Emma Cross, and opening address by the Senior Tutor, Dr Patricia Fara, Riley Auditorium

Panel 1: 11.20-12.05

Chair: Dr Meredeth Shafto, “Clareity CRAs”

11.20 – 11.35   Mark Agius: Recent Adventures in the Treatment of Bipolar Disorder

11.35 – 11.50   Tobias Roeder: Professional Identity of Army Officers in Britain and the Habsburg Monarchy 1740-90

11.50 – 12.05   Jolle Jolles: Social behaviour in animals

Panel 2: 12.10-12.55

Chair: Ed Oughton, MCR President

12.10 – 12.25   Abigail Magrill and Molly Spink: Petals: An assessment of the outcomes of a service for bereavement during childbirth

12.25 – 12.40   Aoibheann McNally: The role of cancer stem cells in Glioblastoma

12.40 – 12.55   Ben Leitch: Intimate Identities: The Individual, Sex, and Neoliberalism in Contemporary Chilean Cinema

 12.55 – 13.40   Lunch break and poster session

 Panel 3: 13.40-14.40

Chair: Emma Cross, Clareity President

13.40 – 13.55   Li Su: Early detection of dementia by a brain scan?

13.55 – 14.10   Riana Betzler: Empathy, Measurement, & Medicine

14.10 – 14.25   Quentin Gouil: Epigenetics and non-mendelian inheritance in plants

14.25 – 14.40   Jessica Crown: ‘Master, if you beat me I will beat you’: Humanism and Tudor Royal Education

14.40 – 15.20    Keynote lecture by Dr Phil Jones: Skin, Sun and Cancer

15.20 – 15.40   Tea Break

 Panel 4: 15.40-16.25

Chair: Dr Alyson Tapp, Graduate Tutor

15.40 – 15.55   Felix Stein: The tragedy of ‘time management’

15.55 – 16.10   Christian Hempel: Doing the Impossible? The Comeback of Polaroid Photography, 2008-2014

16.10 – 16.25   Edgar Turner: Good crop/bad crop? Investigating the potential for oil palm to green up its act

Panel 5: 16.30-17.30

Chair: Robert Wilson, “Clareity Dilettantes”

16.30 – 16.45   Chrysoula Litina: It’s alive! Bioinspired building materials

16.45 – 17.00   Maria Harvey: Santa Caterina at Galatina: Late Medieval Art in Salento at the frontier of the Latin and Orthodox worlds

17.00 – 17.15   Simone Cooper: The role of material efficiency in meeting UK emissions reduction targets

17.15 – 17.30   Sasha Amaya: Spatial Culture and Arctic Architecture in Canada’s North

17.30 – 17.45   Short tea break

 Panel 6: 17.45-18.45

Chair: Dr Patricia Fara, Senior Tutor Clare College

17.45 – 18.00   Tim Beeson-Jones: Viscous Instabilities in Porous Media

18.00 – 18.15   Katherine Jernigan: Tennessee Student Activism, 1954-1970

18.15 – 18.30   Marie Yurkovich: How will we discover new antibiotics?

18.30 – 18.45   Julia Kelsoe: The Role of Arbitration in Elizabethan and early Stuart England

18.45 – Closing of the Symposium by the Senior Tutor, Dr Patricia Fara

18.45 – 19.15   Wine and nibbles in the Garden Room (everybody welcome)

19.30 – Dinner for speakers and chairs


Abstracts

 

Panel 1: 11.20-12.05

 

Recent Adventures in the Treatment of Bipolar Disorder

Mark Agius, CRA, Department of Psychiatry

 

Reassessment of many patients in our clinic has shown that they in fact have Bipolar Disorder rather than Unipolar Depression. This is an illustration that Bipolar Disorder is often under diagnosed. Furthermore, we have found that many of our patients experience mixed affective states or rapid cycling, both of which are linked with increased suicidality. Also, there appears to be a link between many co-morbidities, including Anxiety and OCD , which link with Bipolar Disorder, There appears to be a ‘cascade’, depending on the importance of the dopamine neurotransmitter pathway , and specific polymorphisims of the D2  receptor and enzymes which catabolise dopamine, Comorbid anxiety and bipolar disorder, rapid cycling, and  mixed affective states , leading to increased suicidality. Also, there is a known co-morbidity of bipolar disorder and borderline Personality Disorder. In this context, we are concerned at the high proportion of our patients who have reported childhood sexual abuse.

 

Professional Identity of Army Officers in Britain and the Habsburg Monarchy 1740-90

Tobias Roeder, PhD Student, Faculty of History

 

The paper will be a short outline of the PhD in progress. It will shed light on the idea of a comparative study on army officers in Britain and the Habsburg monarchy in the period of 1740-1790. The preliminary structure of the PhD will be introduced with some examples. This encompasses the question from which social and national/ethnic background 18th century officers came and whether there was a chance for vertical and horizontal mobility in these armies. A further question concerns the professionalization of the officer corps by the states and the officer’s reactions to it. Connected to this is their self-perception as a coherent (or diverse) group as well as their common values, ideas of honour and codes of conduct . The latter also dictated behaviour between officers of different armies. Clare’s own Lord Cornwallis will also feature as one example for the examined persons of the study.

 

Social behaviour in animals

Jolle Jolles, PhD Student, Department of Zoology

 

Social animals must time and coordinate their behaviour to ensure the benefits of grouping, resulting in collective movements and the potential emergence of leaders and followers. However, individuals often differ consistently from one another how they cope with their environment, also known as animal personality, which may affect how individuals use coordination rules and requiring them to compromise. Here we tracked the movements of pairs of three-spined sticklebacks separated by a transparent partition that allowed them to observe and interact with one another in a context containing cover. Individuals differed consistently in their tendency to approach their partner’s compartment during collective movements. The strength of this social attraction was positively correlated with the behavioural coordination between members of a pair but was negatively correlated with an individual’s tendency to lead. Social attraction may form part of a broader behavioural syndrome, as it was predicted by the boldness of an individual, measured in isolation prior to the observation of pairs, and by the boldness of the partner. We found that bolder fish, and those paired with bolder partners, tended to approach their partner’s compartment less closely. These findings provide important insights into the mechanisms that govern the dynamics and functioning of social groups and the emergence and maintenance of consistent behavioural differences.

 

Panel 2: 12.10-12.55

 

Petals: An assessment of the outcomes of a service for bereavement during childbirth

Abigail Magrill and Molly Spink, Undergraduates, Medicine

 

We aimed to evaluate the outcomes of Petals: a charitable organisation in Cambridgeshire. Petals provides counselling for women and couples who have suffered perinatal bereavement, or trauma. Poor aftercare following bereavement has been reported to lead to poor long term outcomes for families. This paper evaluates the effectiveness of counselling interventions and provides recommendations for further studies. Outcomes were recorded in 42 patients using the CORE (Clinical Outcomes in Routine Evaluation) system, developed to assess psychological therapies. The CORE scores were summated into a global representation of severity. Severity decreased across psychological assessment domains in the majority of patients following therapy. A review of the available literature indicates that little is known about the efficacy of therapy for perinatal bereavement and trauma. These original data suggest convincing efficacy and benefits, but the numbers involved are small. Further trials with greater sample sizes are required.

 

The role of cancer stem cells in Glioblastoma     

Aoibheann McNally, PhD Student, Department of Oncology

 

Glioblastoma multiforme (GBM) is the most aggressive primary brain tumour in adults as well as the most common. The current standard therapy is maximal safe resection, followed by radiotherapy and chemotherapy. Despite this multimodel treatment approach, median survival is just 14.6 months. In addition, the majority of patients experience tumour recurrence within 2-3cm of the original resection cavity indicating therapeutic resistance. Glioblastoma stem cells (GSCs) are an aggressive subpopulation of GBM cells believed to drive tumour growth and promote therapeutic resistance. Stem cells are cells that can reproduce themselves and give rise to other kinds of cells. As such they have the ability to repair and replace other tissues in the human body. Similarly cancer stem cells can reproduce themselves, drive proliferation and subsequently sustain the cancer. By targeting these cancer stem cells in GBM it may be possible to reduce tumour recurrence and significantly improve GBM treatment.

 

Intimate Identities: The Individual, Sex, and Neoliberalism in Contemporary Chilean Cinema

Ben Leitch, MPhil Student in Latin American Studies

 

Largely overlooked by Latin American film scholars compared to that of Mexico, Brazil and Argentina, the cinema of Chile is one that has, in the past fifteen years, matured into a medium that expresses and reflects the intimate identities of the Chilean people. Whilst many would say that this novísimo (newest) cinema of Chile has provided an overwhelming emphasis on the middle-class lifestyle and evaded the many socio-economic inequalities that the nation has been recently facing, there is also a large focus on what Saavedra Cerda describes as a “retórica del individuo” (rhetoric of the individual), which mirrors and supports the neoliberal ideology deeply embedded into Chilean society. A striking feature of contemporary Chilean society is undoubtedly the increase of sexuality. Sex and relationships are emerging as themes that are important to Chileans in their everyday lives. In addition, due to the globalization of sexuality, the merging of public and private space can be seen throughout the country. Chile, still a greatly conservative and Catholic country, has become replete with contradictions and double standards as its youth continues to be increasingly influenced by neoliberal policy stemming from European and North American ideology. What has arisen is a generation ready to accept sexuality as a key component of everyday life, yet this generation is restrained by long-standing socio-political and religious doctrine. Contemporary Chilean cinema attempts to uncover the sexual awakening of young Chileans, placed in parallel with a society that is becoming increasingly more liberal, but is not yet liberal enough.

 

Panel 3: 13.40-14.40

 

Early detection of dementia by a brain scan?

Li Su, CRA, Department of Psychiatry

 

Dementia is a major debilitating condition for people at old age, and there is currently no cure for most types of dementia especially for those caused by neurodegenerative diseases. Thus, it is importance to treat and prevent these diseases by modifying risk factors in early stages. However, early detection of conditions like Alzheimer’s disease is very difficult because the clinical symptoms and brain structural changes only occur decades after the pathology starts. So, it is critical to develop techniques that provide pathological information in living brains. I will show a novel MRI based technique that images the biochemical content rather than structure of the brain. It can reflect potential damages in tissue integrity due to Alzheimer’s and related diseases. From this special scans, we can found abnormality in tissues that otherwise look normal in conventional MRI scans. This method is akin to “in vivo histology”, and has the potential to be used in clinic where MRI is readily available.

 

Empathy, Measurement, & Medicine

Riana Betzler, PhD Student, Department of History and Philosophy of Science

 

In contemporary society, empathy is viewed as a desirable trait to have because it is thought to motivate prosocial—possibly even altruistic—behaviour, facilitate a sense of community, and play an important role in moral development.  Many people hope to cultivate a “culture of empathy” by improving their own and others’ capacity for it (e.g. Obama, 2006).  But questions remain as to how best to do this.  Social scientists have stepped in to figure out whether empathy can be taught and what means might be used most effectively to do so.  This endeavour has highlighted several issues surrounding the measurement and cultivation of empathy.  Social scientists who hope to find ways to cultivate empathy need reliable measurement techniques.  Without such techniques, they cannot track whether their interventions work.  In this paper, I explore some of the challenges to finding reliable measurement techniques—and, in turn, teaching methods—posed by the instability of the definition of empathy.  I consider these issues in the case of medical empathy in particular.

 

Epigenetics and non-mendelian inheritance in plants

Quentin Gouil, PhD Student, Department of Plant Sciences

 

150 years ago, Gregor Mendel established the laws of genetic inheritance from his work on peas. 50 years later, departures from the ‘Mendelian inheritance’ were first noticed, in a process called paramutation: although the DNA sequence remains unchanged, its epigenetic state (roughly, is the gene on or off) is durably altered and the character under scrutiny does not segregate in later generations. Such deviations have since been identified in multiple organisms, from maize to mice. I am studying paramutation in tomatoes to understand its prevalence and mechanism.  Paramutation occurs in hybrids at a frequency far higher than previous isolated reports suggest. I will discuss the consequences of paramutation on our understanding of hybrid vigour and adaptive evolution.

 

‘Master, if you beat me I will beat you’: Humanism and Tudor Royal Education

Jessica Crown, PhD Student, Department of History

 

Renaissance humanists were particularly concerned with educating children from the earliest years in good letters, by which they meant the literature of the ancient Romans and Greeks. As Geoffrey Elton, a former fellow of this college, put it, they were ‘born educators with well-worked out theories of good education’, theories which have proven highly influential centuries later. They believed that it was especially important that a future monarch was properly educated, since he (or occasionally she) would have the care of an entire kingdom. Beginning with Prince Arthur, whose tutor claimed that he had memorised or read an impressive range of authors, including Cicero, Homer and Quintilian, Tudor royal children all received an education along humanist lines. This talk will explore the case study of Henry Fitzroy, Henry VIII’s illegitimate son, and his tutor Richard Croke. Fitzroy preferred hunting and sports to study, much like his father, who had confessed ten years after his accession to his chief minister Cardinal Wolsey that he found writing ‘somewhat tedious and painful.’ The acclaimed Greek scholar Croke was ambitious and determined, more than a match for a pupil who, as this paper’s title indicates, would not be cowed by threats. I will discuss the background leading up to Croke’s appointment, his techniques and materials for teaching Fitzroy, and perhaps most importantly, how far did Croke encourage Fitzroy to share his zeal for classical studies?

 

Panel 4: 15.40-16.25

 

The tragedy of ‘time management’

Felix Stein, PhD Student, Department of Social Anthropology

 

After a brief introduction into economic anthropology and a presentation of my fieldsite, I will present an argument about the tragedy of ‘time management’. My research subjects, who are modern day business consultants are absolute masters at ‘managing’ their time efficiently, so as to gain more of it. However, their techniques rarely fulfil their purpose. I will argue that this is not coincidental or merely due to external factors but that in fact, currently fashionable ‘time management’ techniques are tragic in that they produce the opposite of what they are trying to achieve. This is because they co-create an acute temporality, marked by an emphasis on finitude and individual responsibility, which risks pushing people into ever-greater busyness.

 

Doing the Impossible? The Comeback of Polaroid Photography, 2008-2014

Christian Hempel, PhD Student, Judge Business School

 

2008 was supposed to be the end of Polaroid photography: After declining for years due to digital technology, the Polaroid Corporation went bankrupt and stopped production. At this time, a new organisation called “The Impossible Project” sprang into action to take over the last remaining factory and bring Polaroid photography back. Against all odds, Polaroid photography has not just survived for six years but has made a comeback, with film sales tripling over the period. This study explores how this surprising development unfolded and how organisations can generate renewal in unlikely places.

 

Good crop/bad crop? Investigating the potential for oil palm to green up its act

Edgar Turner, Fellow, Department of Zoology

 

Oil palm cultivation is one of the major drivers of rainforest loss worldwide and yet oil palm is also among the most important sources of vegetation oil and key to the revenue of an increasing number of tropical countries. Arguably the biggest problem with oil palm is that it grows best in those parts of the world that support tropical rainforests and the diverse range of animals and plants they contain. However, despite their reputation as the bad guys of the agricultural world, oil palm companies can be surprisingly environmentally aware, with non-chemical pest-control methods being practiced as a standard across large parts of the industry. This talk will investigate some new research, based in Riau, Sumatra, that investigates ways that plantations can be managed to benefit biodiversity without reducing yield. Oil palm plantations can never support the diversity of rainforests, but much can still be done to make them more biofriendly and potentially sustainable.

 

Panel 5: 16.30-17.30

 

It’s alive! Bioinspired building materials

Chrysoula Litina, PhD Student, Department of Engineering

 

Referring to nature to solve a number of engineering problems, bio-inspiration, is not novel. Examples are found in various forms from everyday materials like Velcro, to high resolution ‘retina’-mimicking lenses and the aerodynamic designs in aviation and automotive industry. These rely on mimicking different coping mechanisms and behaviours of living organisms; modifying and adapting them to overcome design problems. One of the most fascinating natural mechanisms is self-regulation and self-repair. This forms a question: Is it possible to mimic such behaviour and if so can materials heal themselves the same way natural organisms address wounds or inflictions? Namely holistically, systemically and in multiple levels.  A proposed solution evolves the development of an autonomic system by incorporating an encapsulated liquid healing compound.  Thus, when cracking occurs the repair agent can be released, and allow recovery of the original properties. Considering the range of potential applications scientists have been working on a number of material classes from re-healable polymer composites to self-repairing metals and ceramics. In this context this talk focuses on one particular composite, concrete.  It is the world’s most used building material with an innate flaw, cracking. To control the cracking a self-healing approach is put forward designing and using microscopic capsules to deliver repair agents that target known areas of stress build-up inside the composite matrix. Although results confirm the self-healing concept, the challenge remains in creating materials highly adaptive, capable of responding to complex external triggers, recovering their properties manifold.

 

Santa Caterina at Galatina: Late Medieval Art in Salento at the frontier of the Latin and Orthodox worlds

Maria Harvey, PhD Student, Department of History of Art

 

The church of Santa Caterina a Galatina is undoubtedly the most well-preserved and exceptional monument of the Middle Ages in Southern Italy outside of Naples. Built in 1385-91, completely frescoed by 1435 and most probably commissioned by Maria d’Enghien, Countess of Lecce and Queen of Naples, the church has received very little scholarly interest. Santa Caterina was built in an area of Italy – Salento, the heel of the Italian boot – where a dialect called Griko, derived from Greek, continues to be spoken and where Orthodox clergy existed until the early twentieth century. My research focuses on thinking about how this exceptional artistic monument functioned in relation to the local communities, which were, and still are, characterised by a high-degree of cross-cultural interaction. My talk, however, will have a wider scope and consider various Southern Italian medieval monuments, including other regions such as Sicily, Calabria, Basilicata and Molise. It will aim to demonstrate how my PhD case study of Medieval Salento can change, problematise and challenge our contemporary concept of Medieval Italy, which continues too often to be associated with Dante’s Divine Comedy, Florence and Tuscany. Hopefully, it will also demonstrate how this traditional understanding of Italy as formed by two binary units, the civilised and rich North and the savage and poor South, influences all discourses on the country: from medieval Art History to current politics.

 

The role of material efficiency in meeting UK emissions reduction targets

Simone Cooper, PhD Student, Department of Engineering

 

The UK has committed to reducing its domestic greenhouse gas emissions by at least 80% by 2050. Most mitigation research and policies have focused on supply-side measures – reducing the amount of emissions per unit of output produced. However, material efficiency – delivering output with fewer new material inputs – is an important complementary demand-side measure. This talk will explore the emissions abatement potential of some different material efficiency strategies and estimate the potential scale of macro-level impacts using steel as a case study.

 

Spatial Culture and Arctic Architecture in Canada’s North

Sasha Amaya, MPhil History and Philosophy of Architecture and Urban Studies

 

Despite sedentarization over the last 75 years, Inuit have largely resisted the behaviours and habits suggested by Euro-Canadian prefabricated housing. In this talk, I aim to trace some of the approaches architects have taken to building northern housing, and why these approaches have not proved entirely successful. Given the resiliency of Inuit culture and lifestyle, I suggest that taking account of physical representations of Inuit qaujuimajatuqangit, or that which “Inuit… have known for a long time,” is essential in building more culturally appropriate and physically sustainable northern housing in the Canadian north.

 

Panel 6: 17.45-18.45

 

Viscous Instabilities in Porous Media

Tim Beeson-Jones, PhD Student, Department of Earth Sciences

 

When a fluid of lower viscosity displaces one of higher viscosity in a porous media, the interface between the two fluids can be unstable and the displacing fluid has a tendency to finger. This is pertinent to the recovery of oil by water in an oil reservoir. Sometimes it is beneficial to inject an annulus of a third fluid in between the oil and the water, and we explore the highest flow rate that can be injected whilst keeping the interface stable.

 

Tennessee Student Activism, 1954-1970

Katherine Jernigan, PhD Student, Department of History

 

I will speak about my PhD research, on student activism in Tennessee between the 1950s and 1970.  The 1960s were notorious as a period of student uprisings and awakening worldwide.  However, scholarly studies of activism in the United States have traditionally focused on University of California at Berkeley and Columbia University, campuses in the west and northeast of the country.  The South, an area of tremendous black student organisation during the Civil Rights Movement, has surprisingly been overlooked.  Although a region renowned for its political conservatism, white and black students at universities in the state nevertheless organised and campaigned over issues of race, foreign policy, labour, and student rights on campus.  The period witnessed remarkable change on campuses in the student body’s racial and gender composition.  Tennessee—often known as ‘the Three States of Tennessee’—allows a fascinating study of student activism in a southern context, given the variability of the state’s geography and demographics, from the mountainous and heavily white eastern portion, to the western region where blacks were far more numerous and plantation agriculture more pervasive.  Through archival research, and interviews with former student activists I provide a history of student activism across the major public and private universities in the state.  My talk outlines the major characters and events of the narrative, from the Brown decision invalidating segregated public education in 1954 to the riots following shootings at Kent State University in 1970, and highlights the personal connection I have to my research as a native Tennessean.

 

How will we discover new antibiotics?

Marie Yurkovich, PhD student, Department of Biochemistry

 

Decades of antibiotic misuse has given rise to widespread bacterial resistance, resulting in what the WHO has deemed a serious threat to global health.  With the very real possibility of a post-antibiotic era looming, how will we come up with new therapeutics?  Currently, 90% of all antibiotics in use are produced from the class of soil bacteria known as Actinobacteria. While these bacteria are arguably the richest source of chemical diversity known to man, the number of new antibiotics coming to clinic has fallen sharply since “the golden age of antibiotic discovery” between the 1950s-80s.  However, with the emergence of whole genome sequencing, we now recognise that genetic potential of these species far outpaces what we once thought.  It appears that a large proportion of the pathways within these species that are predicted to encode for a bioactive molecule are silent or ‘cryptic’.  I would like to highlight some strategies for how we are actively ‘awakening’ these pathways in order to gain access to new therapeutic molecules, for the production of antibiotics or otherwise.

 

The Role of Arbitration in Elizabethan and early Stuart England

Julia Kelsoe, MPhil Early Modern History

 

The role arbitration has played in Elizabethan and early Stuart (1558-1642) dispute resolution has received far less attention in scholarship than that of litigation or of the courts system more generally. Despite recent claims that arbitration was utilised and often preferred by contemporaries of the period, the study of arbitration has remained a ‘footnote to the history of more formal legal institutions’. This is likely due to the lack of primary source material on arbitration and to the overemphasis on the ‘rule of law’ in previous legal scholarship. An examination of legal suits from the period, however, demonstrates the frequency with which arbitration was used to resolve disputes both within the courts system and extra-judicially. More importantly, it elucidates the courts’ tolerance of arbitration as a viable alternative to the courts’ own jurisdiction and procedure. Although this analysis is in no way comprehensive, it may help rectify the lack of scrutiny of Elizabethan and early Stuart arbitration within legal scholarship that has served to underemphasize the historical approval of and reliance on arbitration.

 

 

Poster Abstracts

 

An Audit Of Obsessive Compulsive Disorder in A Bedford [UK] Community Mental Health Team

Mark Agius, CRA, Department of Psychiatry

 

OCD is a condition seen often in Community Mental Health Teams in England. It is treated with medication and psychology. We wanted to assess what co-morbidities were present in our OCD patients, with which medications they were being treated, and whether patients had received psychological treatment. On assessment it is clear that a very large number of the OCD patients in our cohort are complex patients who have not responded to first line treatment, such as SSRIs or basic psychology, and who suffer from co-morbidities. Treatment of these patients, while oriented towards the achievement of recovery, is also relatively complex and long term.

 

The impact of guidance on citalopram’s effects on the QT period on the practice of clinicians

Mark Agius, CRA, Department of Psychiatry

 

In 2011, the FDA published guidelines regarding the prescribing of citalopram and escitalopram following publication of evidence showing prolongation of the QT period at therapeutic doses.  This paper looked at the impact of these guidelines on the prescribing practices of clinicians in one centre.  It showed that clinicians have changed practices in accordance with the guidelines for citalopram but no clear patterns were seen in escitalopram or when looking individually at the specific guidelines for patients over 60 years of age.  There was no evidence of increased concordance by clinicians with the guidelines in patients taking other QT prolonging drugs who are at additional risk.  Overall, the guidelines have made an impact on practice but this is partial and 2% of all patients still remain on regimes that do not fit the guidelines.  The possible reasons for this are explored.

 

Ocean acidification does not impact shell growth or repair in the Antarctic brachiopod

Emma Cross, PhD Student, Department of Earth Sciences

 

Marine calcifiers are the most vulnerable organisms to ocean acidification, however, there are limited long-term studies on the impacts of increased pCO2 on these taxa. A 7 month CO2 perturbation experiment was performed on one of the most calcium carbonate dependent species, Liothyrella uva, which inhabits the Southern Ocean where the lowest carbonate ion saturation levels are found. The effects of the predicted environmental conditions in 2050 and 2100 on the growth rate and ability to repair shell in L.uva were tested with four treatments; a low temperature control (0°C, pH7.98), a pH control (2°C, pH8.05), mid-century scenario (2°C, pH7.75) and end-century scenario (2°C, pH7.54). Environmental change impacts on shell repair are rarely studied, but here repair was not affected by either acidified conditions or temperature. Growth rate was also not impacted by low pH. Elevated temperature did, however, increase growth rates. The ability of L.uva to continue, and even increase shell production in warmer and acidified seawater suggests that this species can acclimate to these combined stressors and generate suitable conditions for shell growth at the site of calcification.