We have an excellent set of talks for the next Clareity. Kasia Brzezinska will introduce memoirs of a C18th Polish noblewoman and Daniel Marcos Corchado a Clare Research Associate (CRA) will illustrate us about Neuroblastoma (NB), a childhood cancer arising from dysregulated neuronal cells during child development, and an avenue for treatment.
As always there will be pizza, wine and nibbles (promise to bring more wine). Looking forward to seeing you there!
Please find the abstracts below or at:
‘Wirydianna Fiszerowa’s Memoirs: A Noblewoman’s Perspectives on Public and Private Life in Eighteenth-Century Poland’– Kasia Brzezinska
In 1823, three years before her death, the Polish noblewoman Wirydianna Fiszerowa completed her memoirs. She had lived through one of the most tumultuous periods in her country’s history, as Poland went from being one of the largest states in Europe as part of the Polish-Lithuanian Commonwealth, to ceasing to exist on the map altogether. Fiszerowa’s memoirs offer a fascinating glimpse of life in eighteenth and early nineteenth-century Poland, intertwining stories of significant political events with portraits of major historical figures and descriptions of the seemingly mundane everyday existence of a noblewoman. Her account is noteworthy for its extensive portrayal of women’s activities in private and public life, which is the focus of my PhD.
In this talk, I’ll introduce you to eighteenth-century Polish history before explaining what Fiszerowa and her memoirs can tell us about the various roles that noblewomen played in public, private and in-between in eighteenth-century Poland.
‘To differentiate or to divide: that is the question. An overview of this process in the paediatric cancer Neuroblastoma’ – Daniel Marcos Corchado
Cell division and differentiation are closely related events and are common processes undergone by cells during their normal life. A proper balance of both is extremely important for the correct development of the organism. Many components take part in the regulation of these mechanisms, and like an orchestra, all these factors should be accurately regulated in time and space. Small changes in this balance can lead to the dysregulation of the cell division/differentiation process, locking the cells in an irreversible and uncontrolled state of cell proliferation, promoting cancer. The objective of our work is to understand the mechanisms underlying the regulation of these processes, and how cell division and differentiation could be controlled with a therapeutic purpose.
The protein called “Ascl1” is one of the factors that has been shown to play a key role in regulating differentiation during embryonic development. Furthermore, it is particularly elevated and modified in Neuroblastoma (NB), a childhood cancer arising from dysregulated neuronal cells during child development. The use of new models to allow a complete understanding of how gene use changes in cancer compared to normal tissue, has led us to a deeper understanding of how these mechanisms are altered in NB. Using biochemical techniques and different compounds we have been able to chemically modify this factor with a potential therapeutic purpose. These studies point out new therapeutic targets for the treatment of Neuroblastoma.