Gather together for our final Clariety Evening of the academic year! Tonight we will hear research from two graduating MCR members: Maheetha Bharadwaj, and former Clareity president Andrés Bustamante.
‘Figuring out cancer from a preventative perspective’, Maheetha Bharadwaj
According to the NHS, more than 1 in 3 people will develop cancer in their lifetime. Of these cancers, rare and aggressive cancers warrant immediate attention due to the lack of treatments available for these malignancies. Therefore, there exists a strong need to identify targetable genetic factors contributing to the rise of rare and aggressive cancers. Whole exome sequencing (WES) has assisted clinicians and scientists in finding variants that drive many common cancers. This project hopes to use WES to analyze variants from rare and aggressive cancers. Here, we describe the research methodology developed to analyze DNA from blood samples in three different clinical settings. The first example involves a family with two children affected with a rare childhood cancer. The second cohort involves sixteen males with young-onset high-grade aggressive prostate cancer. The third example involves an individual with ovarian clear cell carcinoma whose mother and sister have been diagnosed with gynecological cancers but have not been sequenced. This project briefly describes, compares, and contrasts the methodologies and tools used in revealing candidate variants of interest in both clinical settings. In conclusion, this project reveals variants of interest and a robust methodology for analyzing germline variants from whole-exome sequencing.
‘Miguel Covarrubias’ Search for Origins’, Andrés Bustamante
Public works in downtown Mexico City came to a sudden halt in 1790 when workers uncovered the Calendar Stone, along with two other monumental Aztec stone sculptures: the Stone of Tizoc and the figure of the goddess Coatlicue. Before these discoveries, scholars could only access textual sources—either codices or Spanish chronicles—to study the pre-Conquest Americas. These three masterpieces began to flesh out a three-dimensional pre-Columbian world and transformed the ways in which this past was visualized. Until the 20th century, these works were studied through the lens of natural history, archaeology, and anthropology, but never art. How did pre-Columbian material culture become ‘Art’? In this talk we’ll examine Mexican artist and archaeologist Miguel Covarrubias’ efforts to create a genealogy for pre-Columbian art, and the political implications of this seemingly minor semantic shift for Mexican society and, perhaps unexpectedly, for the development of Modern Art.